If you’ve been searching for a hearty, crowd-pleasing dish with a fun twist, the Cattle Drive Casserole Recipe is your new go-to comfort food. This casserole is packed with seasoned ground beef, vibrant veggies, and creamy layers all topped with a melty cheese blanket that makes every bite deliciously irresistible. Perfect for family dinners or potlucks, this dish combines simple ingredients into a flavor-packed meal that feels like a warm, satisfying hug on a plate. Let me walk you through this beloved recipe that’s as easy to make as it is delightful to eat.

A clean white marble surface with all the ingredients for Cattle Drive Casserole neatly arranged in a visually balanced flat lay: a mound of pinkish lean ground beef next to a small bowl of deep red diced red bell pepper and another bowl with finely chopped pale yellow onion; a small rustic bowl holding bright green diced green chiles; a small heap of golden yellow shredded cheddar Fiesta cheese blend; a measuring cup filled with milky white sour cream alongside a jar with creamy off-white mayonnaise; a small glass bowl with vibrant red mild salsa; a neat pile of textured light beige biscuit mix (Bisquick); a clear glass of water; a small shaker of fine garlic powder and a small ramekin of orange-brown taco seasoning mix. The ingredients are styled with natural light, soft shadows, and a touch of greenery from fresh herbs subtly placed at the edges for warmth. The textures range from creamy, crumbly, juicy, and shredded, creating contrast and depth. Overhead shot, top down view, flat lay photography, professional food styling --ar 1:1 --q 2 --s 750 --v 6.1

Ingredients You’ll Need

The beauty of the Cattle Drive Casserole Recipe lies in its straightforward ingredients that come together to create a complex and comforting flavor profile. Each component adds a unique texture, taste, or splash of color that elevates the whole dish when combined.

  • 1.5 pounds lean ground beef (90/10 or 85/15 works fine): This forms the hearty protein base of the casserole, providing rich, savory flavor without being too oily.
  • 1 piece red bell pepper, seeded and chopped: Adds a pop of sweetness and vibrant red color to brighten the casserole.
  • 1 piece yellow onion, chopped: Infuses the dish with a subtle sweetness and depth as it cooks down.
  • 1 ounce taco seasoning mix: Brings a zesty, southwestern spice blend that gives the casserole its signature kick.
  • 2.5 cups biscuit mix (like Bisquick): Provides a tender, slightly crumbly topping that bakes up golden and delicious—gluten-free options work great too!
  • 1 cup water: Hydrates the biscuit mix creating the perfect dough for the topping.
  • Cooking spray: Used to grease the baking dish, preventing sticking and ensuring easy serving.
  • 0.5 cups sour cream: Adds a cool, tangy creaminess that balances the spices perfectly; light mayo can be used to cut calories.
  • 0.5 cups mayonnaise: Enhances the creamy layer with richness; Greek yogurt is a fun substitute if you want more tang.
  • 4 ounces diced green chiles, drained: These bring a mild kick and a bit of smokiness that elevate the casserole.
  • 1.5 cups cheddar cheese Fiesta Blend, shredded, divided: The star topping that melts gooey and golden, adding both flavor and that irresistible cheese pull.
  • 1 teaspoon garlic powder: Infuses a warm, savory undertone that complements the beef fantastically.
  • 0.5 cups mild salsa: Pours in moisture and flavor, and can be swapped for medium salsa if you prefer more heat.

How to Make Cattle Drive Casserole Recipe

Step 1: Prepare the Beef Mixture

Begin by heating a large skillet over medium-high heat. Add the ground beef, red bell pepper, and chopped onion. Cook until the beef is fully browned and the veggies have softened, about 8 to 10 minutes. Drain any excess grease if necessary, then sprinkle the taco seasoning mix and garlic powder over the beef. Stir in the diced green chiles and mild salsa, allowing all those beautiful southwestern flavors to meld together for another 2 minutes. This mixture forms the savory, spicy heart of the Cattle Drive Casserole Recipe.

Step 2: Prepare the Biscuit Topping

In a medium bowl, combine the biscuit mix with water, sour cream, and mayonnaise. Stir until the dough comes together smoothly. This biscuit dough is going to bake into a fluffy, golden topping that’s the perfect counterpoint to the saucy beef mixture beneath. Don’t overmix — just enough until combined will keep the topping tender and light.

Step 3: Assemble the Casserole

Preheat your oven to 350 degrees Fahrenheit (175 degrees Celsius) and spray a 9×13-inch casserole dish with cooking spray. Spread the cooked beef mixture evenly across the bottom of the dish. Sprinkle half of the shredded cheddar cheese over the beef layer. Then dollop the biscuit dough over the cheese and gently spread it out to cover as evenly as possible — it doesn’t have to be perfect! Finally, top with the remaining cheese to create that fantastic melty crust.

Step 4: Bake to Perfection

Place the casserole in the oven and bake for about 30 minutes, or until the biscuit topping is golden brown and cooked through. You’ll know it’s ready when the cheese is bubbly and the top has a beautiful crust with a light crispness to it. Let it cool for a few minutes before serving so all those flavors have a chance to settle.

How to Serve Cattle Drive Casserole Recipe

Garnishes

The beauty of this casserole is how well it pairs with fresh garnishes to brighten the rich flavors. Try topping your slice with chopped fresh cilantro, sliced green onions, or a dollop of sour cream. A squeeze of lime juice over the top can add a refreshing tang that cuts through the cheesy richness beautifully.

Side Dishes

Cattle Drive Casserole Recipe stands out on its own, but pairing it with a simple green salad or a crispy corn salad balances the meal wonderfully. For a hearty side, try roasted vegetables or Mexican street corn (elote) to complement the southwestern vibe of the casserole.

Creative Ways to Present

If you’re serving this for a potluck or family gathering, consider baking it in individual ramekins for single servings that look charming and keep everyone’s portions neat. Alternatively, spoon it over warm rice or even mashed potatoes for a cozy, rustic twist on presentation that everyone will love.

Make Ahead and Storage

Storing Leftovers

Any leftover Cattle Drive Casserole Recipe can be stored in an airtight container in the refrigerator for up to 4 days. The flavors often deepen when rested, so reheating leftovers can be just as satisfying as freshly baked.

Freezing

You can freeze the casserole either before or after baking. If freezing before baking, assemble the dish and cover it tightly with foil and plastic wrap. Freeze for up to 3 months, then bake straight from frozen, adding extra baking time. For leftovers, transfer into a freezer-safe container and freeze for up to 2 months.

Reheating

Reheat portions in the microwave for quick meals, or warm the entire casserole in a preheated 350-degree oven until heated through and the cheese is melty again, about 15-20 minutes. Cover with foil to prevent drying out, uncover near the end for a crispier top.

FAQs

Can I substitute the ground beef with turkey or chicken?

Absolutely! Ground turkey or chicken can be used to make a lighter version of the Cattle Drive Casserole Recipe. Just be mindful of cooking times, as leaner meats cook a bit faster and can dry out if overcooked.

Is this casserole spicy?

The casserole has a mild to moderate spice level due to the taco seasoning and diced green chiles. You can easily adjust the heat by using mild or medium salsa and seasoning to your preferred taste.

Can I make this recipe gluten-free?

Yes! Simply substitute the regular biscuit mix with a gluten-free biscuit mix, which will maintain the same tender texture for the topping without gluten.

What can I use instead of mayonnaise and sour cream?

If you’re looking to lighten the dish or want a different flavor, Greek yogurt is a fantastic substitute for both. It adds tanginess and creaminess while reducing fat content.

How long will the casserole keep in the fridge after baking?

After baking, the casserole will stay fresh for up to 4 days when stored in an airtight container in the refrigerator. For best texture and flavor, reheat it within this period.

Final Thoughts

There’s something truly special about the Cattle Drive Casserole Recipe — it feels like a cozy, southwestern celebration in every bite. Whether you’re feeding a hungry family or bringing a dish to share with friends, this casserole promises to impress with minimal fuss and maximum flavor. I encourage you to dive in, gather your ingredients, and let this recipe become one of your new favorites in the kitchen!

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Cattle Drive Casserole Recipe

5 Stars 4 Stars 3 Stars 2 Stars 1 Star 4 from 65 reviews
  • Author: admin
  • Prep Time: 25 minutes
  • Cook Time: 30 minutes
  • Total Time: 55 minutes
  • Yield: 8 servings
  • Category: Casserole
  • Method: Baking
  • Cuisine: Tex-Mex

Description

Cattle Drive Casserole is a hearty, flavorful dish featuring seasoned ground beef layered with a biscuit mix crust, cheesy green chiles, and a creamy sour cream and mayonnaise topping. Ideal for family dinners or potlucks, this easy-to-make casserole brings classic Tex-Mex flavors into a comforting, bake-to-perfection meal.


Ingredients

Scale

Meat and Vegetables

  • 1.5 pounds lean ground beef (90/10 or 85/15 works fine)
  • 1 red bell pepper, seeded and chopped
  • 1 yellow onion, chopped
  • 4 ounces diced green chiles, drained

Seasoning and Mixes

  • 1 ounce taco seasoning mix
  • 1 teaspoon garlic powder
  • 2.5 cups biscuit mix (like Bisquick) (Substitute: gluten-free biscuit mix if needed)

Liquids and Sauces

  • 1 cup water
  • 0.5 cups sour cream (Use light mayo to reduce calories)
  • 0.5 cups mayonnaise (Substitutable with Greek yogurt for a tangier layer)
  • 0.5 cups mild salsa (Swap for medium for more heat)
  • 0 spray cooking spray (like Pam)

Cheese

  • 1.5 cups cheddar cheese Fiesta Blend, shredded, divided


Instructions

  1. Prepare the Meat and Vegetables: In a large skillet over medium heat, cook the ground beef until browned and fully cooked, about 8-10 minutes. Drain excess fat. Add the chopped red bell pepper and yellow onion, sautéing until softened, approximately 5 minutes. Stir in the taco seasoning mix and garlic powder, cooking for another 2 minutes to blend the flavors.
  2. Mix the Biscuit Batter: In a mixing bowl, combine the biscuit mix and water. Stir gently until just combined; do not overmix to ensure a light biscuit crust.
  3. Assemble the Casserole: Preheat your oven to 375°F (190°C). Spray a 9×13-inch baking dish with cooking spray. Spread the cooked meat and vegetable mixture evenly in the bottom. Next, layer the diced green chiles and half of the shredded cheese over the meat.
  4. Add the Biscuit Layer: Pour the biscuit batter evenly on top of the meat and chile layer, spreading gently to cover. Sprinkle the remaining shredded cheese evenly over the biscuit batter.
  5. Bake: Place the casserole in the preheated oven and bake for 25-30 minutes or until the biscuit topping is golden brown and cooked through.
  6. Prepare the Creamy Topping: While the casserole is baking, mix the sour cream, mayonnaise, and mild salsa in a small bowl until smooth.
  7. Serve: Remove the casserole from the oven and let it cool for 5 minutes. Cut into 8 servings and serve each piece with a dollop of the creamy topping for added flavor and moisture.

Notes

  • You can substitute light mayo or Greek yogurt in the creamy topping to reduce calories and add tanginess.
  • Use gluten-free biscuit mix if you need to accommodate gluten-free diets.
  • Swap mild salsa for medium or hot salsa if you prefer more heat.
  • For a richer taste, mix extra cheese into the biscuit batter before baking.
  • Leftovers keep well refrigerated for up to 3 days and can be reheated in the oven or microwave.

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